PTEN

Across TCGA patient cohorts, PTEN mutation is significantly associated with the total protein of many other genes, with 120 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTEN-associated genes across cancer lineages are Akt_pS473, Akt_pT308, and eEF2. Each is linked with PTEN in more than 11 cancer types. Because this analysis shows association rather than direction, both PTEN-to-partner and partner-to-PTEN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Akt_pS473 grouped by PTEN-low versus PTEN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTEN→partner) and Y-score (partner→PTEN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Akt_pS473 →	+0.988	+1.154	<.001	<.001	3	12
UCS	Akt_pT308 →	+0.904	+2.807	.002	.046	3	11
UCEC	eEF2 →	+0.242	+0.554	<.001	<.001	3	5
LGG	GSK-3_pS9 →	+0.342	+2.342	.019	.019	3	5
LGG	PRAS40_pT246 →	+0.247	+3.010	.001	.019	3	5
BRCA	GAPDH →	+0.442	+3.459	.036	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 120 associations by consensus.

Akt_pS473 by PTEN expression — UCEC

Explore this box plot interactively →