PTAFR

Across TCGA patient cohorts, PTAFR mutation is significantly associated with the RNA expression of many other genes, with 1,765 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTAFR-associated genes across cancer lineages are DUSP15, SKA1, and BTNL9. Each is linked with PTAFR in more than 1 cancer types. Because this analysis shows association rather than direction, both PTAFR-to-partner and partner-to-PTAFR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DUSP15 grouped by PTAFR-low versus PTAFR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTAFR→partner) and Y-score (partner→PTAFR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DUSP15 →	-0.878	-2.885	.001	.002	3	2
UCEC	SKA1 →	+0.693	+2.917	.002	.001	3	2
UCEC	BTNL9 →	-0.954	-3.427	.006	.005	3	2
SKCM	TMEM126A →	+0.496	+2.826	.003	.001	3	2
UCEC	TMEM126B →	+0.456	+2.708	.006	.003	3	2
UCEC	UFD1 →	+0.413	+3.616	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,765 associations by consensus.

DUSP15 by PTAFR expression — UCEC

Explore this box plot interactively →