PTAFR

Across TCGA pan-cancer cohorts, PTAFR RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated PTAFR data layer compared with 4 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher PTAFR RNA is associated with better overall survival. In most high-consensus cancer types, elevated PTAFR expression acts as an unfavorable survival marker, although some lineages such as SKCM and DLBC show a favorable association.

SKCM, LGG, and UVM are the cancer types where PTAFR RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.408	0.269	<.001	78	view →
LGG	OS	Quartile	All	0.376	0.602	<.001	39	view →
UVM	DFS	Tertile	All	0.368	0.721	.007	32	view →
DLBC	DFS	Tertile	III,IV	1.000	0.187	.007	19	view →
LAML	DFS	Quartile	All	0.463	0.694	.018	12	view →
HNSC	DFS	Quartile	All	0.692	0.522	.004	12	view →
SARC	OS	Tertile	All	0.829	0.687	.009	11	view →
SCLC	DFS	Median	IV	0.137	0.559	.008	10	view →
KIRC	DFS	Quartile	III,IV	0.861	0.523	.011	10	view →
STAD	OS	Median	III,IV	0.295	0.612	.008	9	view →
LUSC	DFS	Median	II,III,IV	0.601	0.872	.012	9	view →
LIHC	OS	Tertile	III,IV	0.356	0.720	.002	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

PTAFR–SKCM (OS)

Open the SKCM breakdown →