PTAFR

Across TCGA pan-cancer cohorts, PTAFR RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of PTAFR’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PTAFR RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PTAFR is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.

KIRC, LUSC, and STAD are the cancer types where PTAFR tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PTAFR RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+1.595	<.001	12	view →
LUSC	Male	II,III,IV	−1.356	<.001	8	view →
STAD	All	All	+1.142	<.001	7	view →
LUAD	All	All	−0.847	<.001	7	view →
THCA	All	IV	+1.557	.010	6	view →
KIRP	All	All	+1.111	.001	6	view →
HNSC	All	All	+0.720	.005	4	view →
CHOL	Female	All	+3.763	<.001	3	view →
KICH	Male	II,III,IV	−1.272	.006	2	view →
ESCA	All	All	+1.489	.030	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

PTAFR–KIRC

Open the KIRC breakdown →