PTAFR

Across TCGA cell cohorts, PTAFR mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible PTAFR-associated genes across cancer lineages are ADAM7, HMHB1, and TPPP2. Each is linked with PTAFR in more than 1 cancer types. Because this analysis shows association rather than direction, both PTAFR-to-partner and partner-to-PTAFR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADAM7 grouped by PTAFR-low versus PTAFR-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTAFR→partner) and Y-score (partner→PTAFR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ADAM7 →	+0.004	+3.345	<.001	.007	3	1
SKIN	HMHB1 →	+0.057	+5.022	<.001	.002	3	1
SKIN	TPPP2 →	+0.085	+5.217	<.001	<.001	3	1
SKIN	FAM71C →	+0.015	+4.095	.001	.009	3	1
SKIN	GALP →	+0.017	+4.415	<.001	.007	3	1
CNS	GIMAP7 →	+0.065	+4.169	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

ADAM7 by PTAFR expression — LARGE_INTESTINE

Explore this box plot interactively →