PSTK

Across TCGA patient cohorts, PSTK protein abundance is significantly associated with the RNA expression of many other genes, with 258 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible PSTK-associated genes across cancer lineages are TTLL1, ZC3H7B, and AMH. Each is linked with PSTK in more than 1 cancer types. Because this analysis shows association rather than direction, both PSTK-to-partner and partner-to-PSTK results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PSTK versus TTLL1 in BRCA, with a Pearson correlation of 0.94.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSTK→partner) and Y-score (partner→PSTK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TTLL1 →	+1.106	+0.759	<.001	.001	3	1
BRCA	ZC3H7B →	+1.016	+0.759	.001	.001	3	1
BRCA	AMH →	+2.824	+0.639	.002	.001	3	1
BRCA	MEGF9 →	+2.270	+0.639	.003	.001	3	1
BRCA	C3orf52 →	+3.849	+0.759	.004	.001	3	1
BRCA	PPP1R8 →	+0.307	+0.640	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 258 associations by consensus.

PSTK vs TTLL1 — BRCA

Explore this scatter interactively →