PSTK

Across TCGA pan-cancer cohorts, PSTK RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of PSTK’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where PSTK RNA is repressed in tumor relative to normal tissue. In most cancer types PSTK is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, LIHC, and KICH are the cancer types where PSTK tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PSTK RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	II,III,IV	−0.426	<.001	8	view →
LIHC	All	III,IV	+0.380	<.001	8	view →
KICH	Male	All	−0.643	<.001	7	view →
COAD	Male	II,III,IV	+0.364	<.001	7	view →
KIRC	Male	III,IV	−0.317	<.001	7	view →
LUSC	All	All	+0.210	.003	5	view →
READ	All	All	+0.341	.011	2	view →
PRAD	All	All	+0.163	.014	2	view →
ESCA	Female	All	+0.419	.011	1	view →
STAD	All	All	+0.184	.047	1	view →
LUAD	All	All	+0.152	.031	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

PSTK–THCA

Open the THCA breakdown →