PSTK

Across TCGA patient cohorts, PSTK mutation is significantly associated with the RNA expression of many other genes, with 724 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSTK-associated genes across cancer lineages are MIR98, LGALS16, and HIKESHI. Each is linked with PSTK in more than 1 cancer types. Because this analysis shows association rather than direction, both PSTK-to-partner and partner-to-PSTK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR98 grouped by PSTK-low versus PSTK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSTK→partner) and Y-score (partner→PSTK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR98 →	+0.396	+2.631	<.001	.007	3	2
BLCA	LGALS16 →	+1.185	+5.018	<.001	.004	3	2
UCEC	HIKESHI →	+0.420	+3.584	.009	.003	3	1
UCEC	FAM177A1 →	+0.470	+3.338	.002	.005	3	1
UCEC	CXADR →	+0.899	+3.595	.002	.001	3	1
UCEC	ZNF18 →	+0.524	+3.202	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 724 associations by consensus.

MIR98 by PSTK expression — UCEC

Explore this box plot interactively →