PSPN

Across TCGA patient cohorts, PSPN mutation is significantly associated with the RNA expression of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSPN-associated genes across cancer lineages are RN7SL248P, GAPDHP56, and RN7SL478P. Each is linked with PSPN in more than 1 cancer types. Because this analysis shows association rather than direction, both PSPN-to-partner and partner-to-PSPN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL248P grouped by PSPN-low versus PSPN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSPN→partner) and Y-score (partner→PSPN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL248P →	+0.192	+5.137	<.001	.003	3	2
UCEC	GAPDHP56 →	+0.128	+4.038	.001	.004	3	2
UCEC	RN7SL478P →	+0.380	+4.354	.002	.002	3	1
UCEC	MIR6781 →	+1.193	+4.043	<.001	.005	3	1
UCEC	LINC01670 →	+0.131	+4.258	<.001	.003	3	1
UCEC	IL21 →	+0.347	+4.026	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

RN7SL248P by PSPN expression — UCEC

Explore this box plot interactively →