PSPN

Across TCGA pan-cancer cohorts, PSPN RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated PSPN data layer compared with 4 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher PSPN RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PSPN expression acts as an unfavorable survival marker, although some lineages such as HNSC and KIRC show a favorable association.

ACC, LIHC, and HNSC are the cancer types where PSPN RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Tertile	All	0.207	0.613	<.001	72	view →
LIHC	DFS	Median	II,III,IV	0.215	0.468	.002	42	view →
HNSC	OS	Quartile	III,IV	0.594	0.276	.002	25	view →
UCS	DFS	Median	IV	0.367	0.952	.001	24	view →
DLBC	DFS	Median	II,III,IV	0.477	1.000	.005	23	view →
KIRC	DFS	Median	All	0.731	0.501	.001	20	view →
PAAD	OS	Tertile	All	0.599	0.272	.001	20	view →
THYM	DFS	Tertile	All	0.952	0.751	.002	19	view →
KICH	OS	Median	II,III,IV	1.000	0.600	.027	12	view →
COAD	DFS	Tertile	IV	0.268	0.631	.004	12	view →
LUAD	DFS	Quartile	All	0.154	0.378	.020	11	view →
SCLC	OS	Median	All	0.745	0.548	.012	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

PSPN–ACC (DFS)

Open the ACC breakdown →