PSMG2

Across TCGA patient cohorts, PSMG2 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSMG2-associated genes across cancer lineages are EGFR_pY1068, JNK_pT183_Y185, and Notch1. Each is linked with PSMG2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSMG2-to-partner and partner-to-PSMG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by PSMG2-low versus PSMG2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSMG2→partner) and Y-score (partner→PSMG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.319	-3.169	.020	.020	3	1
UCEC	JNK_pT183_Y185 →	-0.224	-3.156	.015	.020	3	1
UCEC	Notch1 →	+0.262	+3.169	<.001	.020	3	1
UCEC	STAT3_pY705 →	-0.494	-3.169	<.001	.020	3	1
UCEC	ASNS →	+0.682	+2.999	<.001	.035	3	1
UCEC	Cyclin-E2 →	+0.213	+3.009	.021	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

EGFR_pY1068 by PSMG2 expression — UCEC

Explore this box plot interactively →