PSMG2

Across TCGA pan-cancer cohorts, PSMG2 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated PSMG2 data layer compared with 2 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher PSMG2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PSMG2 expression acts as an unfavorable survival marker, although some lineages such as KIRC and OV show a favorable association.

ACC, LIHC, and KIRC are the cancer types where PSMG2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.210	0.679	<.001	113	view →
LIHC	OS	Tertile	II,III,IV	0.368	0.773	<.001	63	view →
KIRC	DFS	Median	All	0.723	0.526	.005	41	view →
LUAD	OS	Quartile	III,IV	0.273	0.753	<.001	33	view →
OV	OS	Median	III,IV	0.366	0.268	.002	28	view →
UVM	OS	Median	All	0.494	0.853	.011	26	view →
KICH	OS	Tertile	All	0.660	1.000	.018	25	view →
CESC	DFS	Quartile	IV	0.247	0.775	.002	24	view →
DLBC	OS	Tertile	All	1.000	0.586	.011	22	view →
ESCA	OS	Quartile	II,III,IV	0.349	0.598	.003	19	view →
MESO	OS	Median	III,IV	0.732	0.343	.011	18	view →
SKCM	DFS	Quartile	III,IV	0.487	0.166	.013	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

PSMG2–ACC (DFS)

Open the ACC breakdown →