PSMG2

Across TCGA pan-cancer cohorts, PSMG2 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of PSMG2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PSMG2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PSMG2 is over-expressed in tumor, although a few such as KICH and READ show the opposite, repressed pattern.

KIRC, LIHC, and HNSC are the cancer types where PSMG2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PSMG2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+0.424	<.001	11	view →
LIHC	Female	II,III,IV	+0.810	<.001	9	view →
HNSC	All	III,IV	+0.357	.002	9	view →
BLCA	All	III,IV	+0.352	.001	8	view →
KICH	All	All	−0.483	<.001	6	view →
CHOL	All	All	+1.688	<.001	5	view →
STAD	All	II,III,IV	+0.489	<.001	5	view →
READ	All	II,III,IV	−0.272	.004	4	view →
ESCA	All	All	+0.839	.003	3	view →
BRCA	All	III,IV	+0.233	.040	3	view →
LUSC	All	All	+0.212	.007	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

PSMG2–KIRC

Open the KIRC breakdown →