PSME4

Across TCGA cell cohorts, PSME4 mutation is significantly associated with the RNA expression of many other genes, with 484 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PSME4-associated genes across cancer lineages are SCN10A, GGTLC1, and FAM98C. Each is linked with PSME4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSME4-to-partner and partner-to-PSME4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCN10A grouped by PSME4-low versus PSME4-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSME4→partner) and Y-score (partner→PSME4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	SCN10A →	+0.053	+5.000	<.001	.005	3	2
BLOOD_Lymphoma	GGTLC1 →	+0.019	+2.655	<.001	.002	3	2
LARGE_INTESTINE	FAM98C →	+0.534	+1.949	.001	.002	3	2
LARGE_INTESTINE	PPA2 →	+0.523	+2.064	.001	.004	3	2
LARGE_INTESTINE	ORAI2 →	-1.048	-2.459	.003	.006	3	2
LARGE_INTESTINE	RPL29 →	+0.592	+2.458	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 484 associations by consensus.

SCN10A by PSME4 expression — KIDNEY

Explore this box plot interactively →