PSME1

Across TCGA patient cohorts, PSME1 mutation is significantly associated with the RNA expression of many other genes, with 79 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSME1-associated genes across cancer lineages are RNVU1-28, RN7SL375P, and MIR6854. Each is linked with PSME1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSME1-to-partner and partner-to-PSME1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNVU1-28 grouped by PSME1-low versus PSME1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSME1→partner) and Y-score (partner→PSME1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNVU1-28 →	+0.867	+2.857	<.001	.002	3	2
BLCA	RN7SL375P →	+0.250	+5.106	.003	.008	3	1
BLCA	MIR6854 →	+0.663	+5.251	<.001	.006	3	1
HNSC	PAICSP7 →	+0.064	+5.015	<.001	.009	3	1
HNSC	MTND5P33 →	+0.079	+5.015	<.001	.009	3	1
UCEC	MIR6129 →	+0.435	+2.496	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 79 associations by consensus.

RNVU1-28 by PSME1 expression — UCEC

Explore this box plot interactively →