Q-omics provides the consensus-scored PAICSP7 profile across patient tissues and cancer cell-line models. PAICSP7 expression is associated with patient survival in 15 of 34 cancer types, with the highest sampling consensus in BLCA. Among the 18 cancer types available for tumor–normal comparison, PAICSP7 is differentially expressed in 2, with the highest sampling consensus in LUSC. Additionally, PAICSP7 RNA expression shows 5,461 significant pathway-activity associations, with the highest sampling consensus in STAD. Together, these results highlight BLCA, LUSC, and STAD as cancer lineages where PAICSP7 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for PAICSP7 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes PAICSP7 survival associations across molecular data types. PAICSP7 RNA expression shows survival associations in the most cancer types (15). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible PAICSP7 RNA expression–survival associations across cancer types. High PAICSP7 expression shows unfavorable associations in BLCA, KIRC, READ, PAAD, KIRP and ACC. The BLCA Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .014). Together, the overview and detailed table identify BLCA as the clearest survival context for PAICSP7 RNA expression.
This table summarizes PAICSP7 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 2. The strongest signals are observed in LUSC for RNA.
This table ranks reproducible tumor–normal expression differences for PAICSP7. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. PAICSP7 shows lower tumor expression in LUSC and higher tumor expression in BRCA. The LUSC box plot shows higher PAICSP7 RNA expression in normal versus tumor tissue (log2 FC = −0.026, t-test p = .001).
This table shows molecular features associated with PAICSP7 in patient tissues and cancer cell lines. In patient samples, PAICSP7 shows the broadest associations at the RNA and protein expression levels, with STAD recurring as the lineage with the largest associated feature set.
