PSMD8

Across TCGA patient cohorts, PSMD8 mutation is significantly associated with the RNA expression of many other genes, with 182 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSMD8-associated genes across cancer lineages are RN7SKP221, TRDD1, and UBE2V1P4. Each is linked with PSMD8 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSMD8-to-partner and partner-to-PSMD8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP221 grouped by PSMD8-low versus PSMD8-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSMD8→partner) and Y-score (partner→PSMD8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RN7SKP221 →	+0.099	+8.471	<.001	.005	3	1
BRCA	TRDD1 →	+1.367	+9.057	<.001	.003	3	1
CESC	UBE2V1P4 →	+0.134	+5.103	<.001	.008	3	1
CESC	LINC01519 →	+0.024	+5.669	<.001	.003	3	1
CESC	TPT1P11 →	+0.147	+5.418	<.001	.005	3	1
CESC	RN7SL813P →	+0.316	+5.103	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 182 associations by consensus.

RN7SKP221 by PSMD8 expression — BRCA

Explore this box plot interactively →