PSMD8

Across TCGA pan-cancer cohorts, PSMD8 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of PSMD8’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PSMD8 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PSMD8 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

KIRC, COAD, and BLCA are the cancer types where PSMD8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PSMD8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	IV	+0.564	<.001	12	view →
COAD	Female	All	+0.848	<.001	11	view →
BLCA	All	All	+0.830	<.001	11	view →
LIHC	Female	II,III,IV	+1.186	<.001	9	view →
HNSC	Male	All	+0.408	<.001	8	view →
LUSC	All	All	+0.776	<.001	7	view →
LUAD	Female	All	+0.392	<.001	7	view →
UCEC	All	III,IV	+0.655	<.001	6	view →
BRCA	All	III,IV	+0.654	<.001	6	view →
CHOL	Male	All	+1.296	<.001	5	view →
KICH	All	All	−0.512	<.001	5	view →
STAD	All	II,III,IV	+0.504	.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

PSMD8–KIRC

Open the KIRC breakdown →