PSMD8

Across TCGA pan-cancer cohorts, PSMD8 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated PSMD8 data layer compared with 3 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher PSMD8 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PSMD8 expression acts as an unfavorable survival marker, although some lineages such as THCA and SCLC show a favorable association.

UVM, MESO, and ACC are the cancer types where PSMD8 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.420	0.759	<.001	92	view →
MESO	OS	Quartile	All	0.374	0.645	.001	70	view →
ACC	DFS	Median	All	0.426	0.734	<.001	61	view →
LGG	DFS	Median	All	0.639	0.839	<.001	54	view →
LIHC	OS	Median	All	0.445	0.689	<.001	38	view →
READ	OS	Quartile	IV	0.424	0.841	.003	35	view →
HNSC	OS	Tertile	All	0.432	0.763	<.001	34	view →
BLCA	OS	Tertile	II,III,IV	0.544	0.672	.018	28	view →
LAML	DFS	Quartile	All	0.278	0.540	.002	26	view →
THCA	OS	Median	III,IV	0.989	0.892	.002	21	view →
LUAD	OS	Quartile	All	0.340	0.592	.003	18	view →
KIRC	DFS	Quartile	II,III,IV	0.694	0.865	.004	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

PSMD8–UVM (OS)

Open the UVM breakdown →