PSMA8

Across TCGA patient cohorts, PSMA8 mutation is significantly associated with the RNA expression of many other genes, with 694 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSMA8-associated genes across cancer lineages are SNRPCP15, RNU6-949P, and MAPK6P6. Each is linked with PSMA8 in more than 3 cancer types. Because this analysis shows association rather than direction, both PSMA8-to-partner and partner-to-PSMA8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNRPCP15 grouped by PSMA8-low versus PSMA8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSMA8→partner) and Y-score (partner→PSMA8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SNRPCP15 →	+0.073	+4.148	<.001	.006	3	4
COAD	RNU6-949P →	+0.290	+6.568	<.001	<.001	3	3
READ	MAPK6P6 →	+0.095	+4.280	<.001	.007	3	3
UCEC	NCAPH2 →	+0.564	+3.459	.003	.005	3	2
UCEC	POLR2E →	+0.512	+3.459	.008	.005	3	2
BRCA	RN7SL616P →	+0.133	+4.883	.006	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 694 associations by consensus.

SNRPCP15 by PSMA8 expression — UCEC

Explore this box plot interactively →