PSMA8

Across TCGA pan-cancer cohorts, PSMA8 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated PSMA8 data layer compared with 1 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PSMA8 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated PSMA8 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CESC show a favorable association.

HNSC, CESC, and BRCA are the cancer types where PSMA8 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	II,III,IV	0.435	0.217	<.001	112	view →
CESC	OS	Tertile	All	0.773	0.446	<.001	60	view →
BRCA	DFS	Median	All	0.964	0.933	.012	52	view →
UCS	DFS	Tertile	IV	0.132	0.718	.002	36	view →
ESCA	DFS	Median	III,IV	0.497	0.240	.005	28	view →
SKCM	OS	Tertile	All	0.356	0.284	.006	19	view →
UVM	DFS	Median	II,III,IV	0.350	0.562	.026	18	view →
CHOL	DFS	Tertile	All	0.727	0.259	.015	18	view →
LUAD	OS	Quartile	All	0.620	0.364	.022	11	view →
THCA	DFS	Tertile	All	0.889	0.761	.031	9	view →
READ	DFS	Tertile	IV	0.095	0.697	.014	9	view →
SCLC	OS	Tertile	II,III,IV	0.891	0.363	.011	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

PSMA8–HNSC (DFS)

Open the HNSC breakdown →