PSMA8

Across TCGA pan-cancer cohorts, PSMA8 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of PSMA8’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PSMA8 RNA is repressed in tumor relative to normal tissue. In most cancer types PSMA8 is over-expressed in tumor, although a few such as COAD and THCA show the opposite, repressed pattern.

COAD, THCA, and KIRC are the cancer types where PSMA8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PSMA8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	All	−0.192	<.001	10	view →
THCA	All	II,III,IV	−0.122	<.001	7	view →
KIRC	Male	All	+0.069	<.001	6	view →
CHOL	Male	All	+0.115	.046	1	view →
LUSC	Female	All	−0.100	.045	1	view →
ESCA	Female	All	+0.070	.018	1	view →
KICH	All	All	−0.053	.010	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

PSMA8–COAD

Open the COAD breakdown →