PSMA8

Across TCGA patient cohorts, PSMA8 mutation is significantly associated with the immune_cell of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSMA8-associated genes across cancer lineages are DC, CD8+ naive T-cells, and pDC. Each is linked with PSMA8 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSMA8-to-partner and partner-to-PSMA8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DC grouped by PSMA8-low versus PSMA8-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSMA8→partner) and Y-score (partner→PSMA8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	DC →	+0.033	+3.231	.002	.044	3	1
UCEC	CD8+ naive T-cells →	+0.036	+3.186	.008	.010	3	1
UCEC	pDC →	+0.084	+3.032	<.001	.018	3	1
UCEC	Th2 cells →	+0.273	+2.321	.002	.036	3	1
SKCM	MEP →	+0.035	+2.826	.007	.035	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

DC by PSMA8 expression — READ

Explore this box plot interactively →