PSMA8

Across TCGA cell cohorts, PSMA8 RNA expression is significantly associated with the go_rna of many other GO terms, with 819 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PSMA8-associated GO terms across cancer lineages are Regulation of meiosis I, Regulation of immunological synapse formation, and Positive regulation of nervous system development. Each is linked with PSMA8 in more than 2 cancer types. Because this analysis shows association rather than direction, both PSMA8-to-partner and partner-to-PSMA8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of meiosis I grouped by PSMA8-low versus PSMA8-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PSMA8→partner) and Y-score (partner→PSMA8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Regulation of meiosis I →	-0.265	-2.144	<.001	<.001	3	3
BLOOD_Lymphoma	Regulation of immunological synapse formation →	-0.472	-1.181	<.001	<.001	3	3
BLOOD_Lymphoma	Positive regulation of nervous system development →	-0.027	-1.595	.001	.003	3	3
BLOOD_Lymphoma	Myeloid leukocyte migration →	-0.105	-0.975	<.001	.004	3	3
BLOOD_Myeloma	Intracellular magnesium ion homeostasis →	+0.088	+1.527	.005	.005	3	2
BLOOD_Myeloma	Negative regulation of bone mineralization →	-0.174	-2.168	.007	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 819 associations by consensus.

Regulation of meiosis I by PSMA8 expression — BLOOD_Myeloma

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