PSMA8

Across TCGA cell cohorts, PSMA8 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible PSMA8-associated genes across cancer lineages are TMEM244, OR2T35, and OR10G2. Each is linked with PSMA8 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSMA8-to-partner and partner-to-PSMA8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMEM244 grouped by PSMA8-low versus PSMA8-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSMA8→partner) and Y-score (partner→PSMA8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TMEM244 →	+0.688	+5.415	<.001	.004	3	1
SKIN	OR2T35 →	+0.013	+5.415	<.001	.004	3	1
SKIN	OR10G2 →	+0.023	+6.022	<.001	.001	3	1
SKIN	CACNG3 →	+0.006	+6.022	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

TMEM244 by PSMA8 expression — LARGE_INTESTINE

Explore this box plot interactively →