PSEN2

Across TCGA patient cohorts, PSEN2 mutation is significantly associated with the RNA expression of many other genes, with 1,229 significant associations in total. COAD shows the largest number of these associations.

The most reproducible PSEN2-associated genes across cancer lineages are MIR548BA, CDCA2, and BRI3BP. Each is linked with PSEN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSEN2-to-partner and partner-to-PSEN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR548BA grouped by PSEN2-low versus PSEN2-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSEN2→partner) and Y-score (partner→PSEN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MIR548BA →	+0.403	+7.954	<.001	.008	3	2
COAD	CDCA2 →	+0.969	+3.472	<.001	.002	3	2
COAD	BRI3BP →	+0.639	+3.499	<.001	.002	3	2
COAD	GAS2L1 →	+0.634	+3.459	.005	.005	3	2
COAD	LINC02195 →	+1.208	+3.472	<.001	.002	3	2
COAD	LINC02446 →	+1.293	+3.472	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,229 associations by consensus.

MIR548BA by PSEN2 expression — HNSC

Explore this box plot interactively →