PSEN2

Across TCGA pan-cancer cohorts, PSEN2 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated PSEN2 data layer compared with 5 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher PSEN2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PSEN2 expression acts as an unfavorable survival marker, although some lineages such as UCEC and DLBC show a favorable association.

KIRP, ACC, and LGG are the cancer types where PSEN2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.886	0.972	<.001	90	view →
ACC	DFS	Median	All	0.242	0.668	<.001	54	view →
LGG	OS	Median	All	0.733	0.886	<.001	54	view →
LIHC	OS	Tertile	All	0.689	0.878	<.001	37	view →
CESC	DFS	Tertile	All	0.616	0.836	<.001	36	view →
SKCM	OS	Tertile	All	0.257	0.382	<.001	36	view →
HNSC	DFS	Quartile	All	0.299	0.468	.005	35	view →
UCEC	OS	Median	IV	0.894	0.598	.007	16	view →
DLBC	DFS	Tertile	III,IV	1.000	0.241	.017	14	view →
SCLC	OS	Median	All	0.799	0.609	.019	11	view →
CHOL	DFS	Quartile	II,III,IV	0.180	0.697	.024	9	view →
SARC	OS	Tertile	All	0.939	0.751	.006	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

PSEN2–KIRP (OS)

Open the KIRP breakdown →