PSEN2

Across TCGA cell cohorts, PSEN2 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PSEN2-associated genes across cancer lineages are RNASE9, POTEB, and OR1P1. Each is linked with PSEN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSEN2-to-partner and partner-to-PSEN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNASE9 grouped by PSEN2-low versus PSEN2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSEN2→partner) and Y-score (partner→PSEN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	RNASE9 →	+0.022	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	POTEB →	+0.012	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR1P1 →	+0.058	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	MYH7 →	+0.016	+4.887	<.001	.009	3	1
SKIN	GUCA2B →	+0.116	+4.415	<.001	.007	3	1
LARGE_INTESTINE	NLRP2 →	+1.894	+3.364	.006	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

RNASE9 by PSEN2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →