PSEN1

Across TCGA patient cohorts, PSEN1 protein abundance is significantly associated with the RNA expression of many other genes, with 6,610 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PSEN1-associated genes across cancer lineages are BTBD7, ENTPD5, and MGP. Each is linked with PSEN1 in more than 3 cancer types. Because this analysis shows association rather than direction, both PSEN1-to-partner and partner-to-PSEN1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PSEN1 versus BTBD7 in LSCC, with a Pearson correlation of 0.39.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSEN1→partner) and Y-score (partner→PSEN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	BTBD7 →	+0.413	+0.249	<.001	.002	3	4
BRCA	ENTPD5 →	+0.957	+0.401	.004	.008	3	4
HNSC	MGP →	-1.050	-0.348	<.001	.001	3	3
HNSC	MAN1C1 →	-0.620	-0.455	<.001	<.001	3	3
HNSC	PTGIS →	-1.317	-0.469	<.001	<.001	3	3
HNSC	RHOJ →	-0.523	-0.390	.008	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,610 associations by consensus.

PSEN1 vs BTBD7 — LSCC

Explore this scatter interactively →