PSEN1

Across TCGA pan-cancer cohorts, PSEN1 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated PSEN1 data layer compared with 3 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher PSEN1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PSEN1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and BRCA show a favorable association.

UVM, KIRC, and ACC are the cancer types where PSEN1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	II,III,IV	0.328	0.646	<.001	91	view →
KIRC	OS	Median	All	0.714	0.553	<.001	67	view →
ACC	DFS	Quartile	All	0.264	0.853	<.001	59	view →
BRCA	DFS	Tertile	III,IV	0.937	0.812	.005	54	view →
PAAD	DFS	Quartile	All	0.231	0.613	.002	38	view →
LIHC	OS	Median	All	0.611	0.761	.001	30	view →
CESC	DFS	Tertile	All	0.649	0.828	.003	28	view →
UCS	DFS	Tertile	IV	0.843	0.250	.024	24	view →
BLCA	DFS	Quartile	All	0.246	0.419	.007	23	view →
UCEC	DFS	Quartile	III,IV	0.895	0.693	.003	20	view →
HNSC	OS	Quartile	All	0.264	0.601	.003	17	view →
PRAD	DFS	Tertile	All	0.943	0.848	.002	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

PSEN1–UVM (DFS)

Open the UVM breakdown →