PSD4

Across TCGA patient cohorts, PSD4 mutation is significantly associated with the RNA expression of many other genes, with 5,812 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSD4-associated genes across cancer lineages are REXO1L8P, HIRIP3, and BUB3. Each is linked with PSD4 in more than 3 cancer types. Because this analysis shows association rather than direction, both PSD4-to-partner and partner-to-PSD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, REXO1L8P grouped by PSD4-low versus PSD4-high in GBM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSD4→partner) and Y-score (partner→PSD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	REXO1L8P →	+0.052	+4.273	<.001	.008	3	3
COAD	HIRIP3 →	+0.580	+3.321	<.001	.009	3	3
UCEC	BUB3 →	+0.493	+3.245	<.001	<.001	3	3
UCEC	SKA1 →	+0.759	+2.110	<.001	<.001	3	3
UCEC	PCNT →	+0.466	+1.857	<.001	<.001	3	3
UCEC	GMEB1 →	+0.246	+1.637	.008	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,812 associations by consensus.

REXO1L8P by PSD4 expression — GBM

Explore this box plot interactively →