PSD4

Across TCGA pan-cancer cohorts, PSD4 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated PSD4 data layer compared with 8 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher PSD4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PSD4 expression acts as an unfavorable survival marker, although some lineages such as SKCM and HNSC show a favorable association.

KICH, SKCM, and HNSC are the cancer types where PSD4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	OS	Quartile	II,III,IV	0.280	1.000	<.001	77	view →
SKCM	OS	Tertile	All	0.419	0.230	<.001	69	view →
HNSC	DFS	Median	All	0.749	0.640	.003	69	view →
LGG	OS	Median	All	0.337	0.532	<.001	51	view →
BLCA	OS	Tertile	II,III,IV	0.799	0.638	.001	40	view →
STAD	OS	Median	All	0.742	0.630	.006	34	view →
ESCA	DFS	Median	All	0.601	0.405	.002	31	view →
LIHC	OS	Quartile	All	0.803	0.586	<.001	31	view →
SCLC	DFS	Tertile	All	0.703	0.442	.008	26	view →
KIRC	DFS	Quartile	II,III,IV	0.633	0.312	.015	24	view →
THYM	OS	Median	All	1.000	0.743	.001	18	view →
LAML	DFS	Median	All	0.477	0.655	.009	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

PSD4–KICH (OS)

Open the KICH breakdown →