PRX

Across TCGA patient cohorts, PRX mutation is significantly associated with the RNA expression of many other genes, with 5,845 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRX-associated genes across cancer lineages are LARP1B, MX2, and CDCA2. Each is linked with PRX in more than 3 cancer types. Because this analysis shows association rather than direction, both PRX-to-partner and partner-to-PRX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LARP1B grouped by PRX-low versus PRX-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRX→partner) and Y-score (partner→PRX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LARP1B →	+0.644	+2.754	<.001	<.001	3	4
UCEC	MX2 →	-0.672	-2.652	<.001	<.001	3	4
UCEC	CDCA2 →	+0.745	+2.440	<.001	<.001	3	4
UCEC	RAET1K →	+0.226	+2.119	.008	.002	3	4
SKCM	TOMM40 →	+0.357	+1.542	.001	.008	3	4
STAD	SPC25 →	+0.740	+3.700	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,845 associations by consensus.

LARP1B by PRX expression — UCEC

Explore this box plot interactively →