PRX

Across TCGA pan-cancer cohorts, PRX RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated PRX data layer compared with 9 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher PRX RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated PRX expression acts as an unfavorable survival marker, although some lineages such as KIRC and UCS show a favorable association.

KIRC, UCS, and COAD are the cancer types where PRX RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.739	0.532	<.001	108	view →
UCS	DFS	Tertile	III,IV	0.585	0.146	.001	64	view →
COAD	DFS	Quartile	II,III,IV	0.358	0.802	<.001	46	view →
BRCA	OS	Tertile	III,IV	0.915	0.768	.001	35	view →
THYM	DFS	Tertile	All	0.945	0.657	.009	23	view →
LIHC	DFS	Tertile	All	0.354	0.509	.001	18	view →
ESCA	OS	Quartile	II,III,IV	0.772	0.329	.002	17	view →
UVM	OS	Median	All	0.718	0.463	.019	16	view →
SARC	DFS	Quartile	All	0.772	0.530	.005	15	view →
SCLC	DFS	Quartile	III,IV	0.773	0.380	.021	14	view →
LUSC	DFS	Median	IV	0.134	0.827	.014	14	view →
HNSC	DFS	Quartile	III,IV	0.525	0.305	.002	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

PRX–KIRC (DFS)

Open the KIRC breakdown →