PRX

Across TCGA pan-cancer cohorts, PRX RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of PRX’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where PRX RNA is repressed in tumor relative to normal tissue. In most cancer types PRX is over-expressed in tumor, although a few such as LUAD and THCA show the opposite, repressed pattern.

LUAD, THCA, and KIRP are the cancer types where PRX tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PRX RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	All	−3.419	<.001	11	view →
THCA	All	All	−0.475	<.001	11	view →
KIRP	All	II,III,IV	−1.584	<.001	9	view →
LIHC	Female	II,III,IV	+1.400	<.001	9	view →
LUSC	Female	II,III,IV	−4.381	<.001	8	view →
BLCA	Male	IV	−2.152	<.001	8	view →
COAD	Female	II,III,IV	−0.645	<.001	8	view →
KIRC	All	All	−0.406	<.001	7	view →
UCEC	All	All	−2.025	<.001	6	view →
BRCA	Female	II,III,IV	−1.373	<.001	6	view →
KICH	Male	All	−1.201	<.001	5	view →
CHOL	All	All	+1.746	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

PRX–LUAD

Open the LUAD breakdown →