PRX

Across TCGA patient cohorts, PRX mutation is significantly associated with the total protein of many other genes, with 76 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRX-associated genes across cancer lineages are Caspase-7-cleavedD198, 4E-BP1_pT70, and INPP4B. Each is linked with PRX in more than 3 cancer types. Because this analysis shows association rather than direction, both PRX-to-partner and partner-to-PRX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by PRX-low versus PRX-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRX→partner) and Y-score (partner→PRX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.405	+1.756	.015	.003	3	4
SKCM	4E-BP1_pT70 →	+0.167	+1.865	.011	.004	3	4
UCEC	INPP4B →	-0.184	-1.584	.043	.007	3	3
UCEC	p70-S6K_pT389 →	-0.133	-1.415	.013	.040	3	3
SKCM	FoxM1 →	+0.322	+2.807	<.001	.002	3	3
STAD	FASN →	+0.405	+3.015	.020	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 76 associations by consensus.

Caspase-7-cleavedD198 by PRX expression — UCEC

Explore this box plot interactively →