PRX

Across TCGA cell cohorts, PRX mutation is significantly associated with the RNA expression of many other genes, with 374 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRX-associated genes across cancer lineages are ALDH6A1, TMEM268, and CYB5D1. Each is linked with PRX in more than 2 cancer types. Because this analysis shows association rather than direction, both PRX-to-partner and partner-to-PRX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ALDH6A1 grouped by PRX-low versus PRX-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRX→partner) and Y-score (partner→PRX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ALDH6A1 →	+1.081	+3.064	<.001	.009	3	2
LARGE_INTESTINE	TMEM268 →	+0.701	+3.212	.004	.006	3	2
LARGE_INTESTINE	CYB5D1 →	+1.225	+3.234	<.001	.004	3	2
LARGE_INTESTINE	ZNF286B →	+1.031	+3.299	<.001	.004	3	2
URINARY_TRACT	LRIT2 →	+0.036	+5.087	<.001	.004	3	1
URINARY_TRACT	GPX5 →	+0.243	+5.087	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 374 associations by consensus.

ALDH6A1 by PRX expression — LARGE_INTESTINE

Explore this box plot interactively →