PRTG

Across TCGA cell cohorts, PRTG mutation is significantly associated with the RNA expression of many other genes, with 501 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRTG-associated genes across cancer lineages are ADGRE3, OR5H8, and SULT2A1. Each is linked with PRTG in more than 1 cancer types. Because this analysis shows association rather than direction, both PRTG-to-partner and partner-to-PRTG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADGRE3 grouped by PRTG-low versus PRTG-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRTG→partner) and Y-score (partner→PRTG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	ADGRE3 →	+0.035	+4.584	<.001	.001	3	1
LUNG_NSCLC_LUSC	OR5H8 →	+0.094	+4.108	<.001	.005	3	1
LUNG_NSCLC_LUAD	SULT2A1 →	+0.182	+4.149	<.001	<.001	3	1
LUNG_NSCLC_LUAD	ODAM →	+1.700	+3.584	<.001	.007	3	1
LUNG_NSCLC_LUAD	TSHB →	+0.052	+3.604	<.001	.004	3	1
LUNG_NSCLC_LUAD	SLC7A13 →	+0.008	+3.887	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 501 associations by consensus.

ADGRE3 by PRTG expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →