Across TCGA cell cohorts, PRSS55 mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible PRSS55-associated genes across cancer lineages are POU3F4, TEX13A, and IL36A. Each is linked with PRSS55 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRSS55-to-partner and partner-to-PRSS55 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRSS55→partner) and Y-score (partner→PRSS55) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	POU3F4 →	+0.454	+4.930	<.001	.008	3	2
BLOOD_Leukemia	TEX13A →	+0.049	+4.969	<.001	.003	3	2
SOFT_TISSUE	IL36A →	+0.038	+4.930	<.001	.008	3	1
SOFT_TISSUE	OR2D3 →	+0.028	+4.930	<.001	.008	3	1
SOFT_TISSUE	SNTN →	+0.023	+5.977	<.001	.001	3	1
SOFT_TISSUE	SPANXN4 →	+0.929	+4.930	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Exploration

PRSS55 survival (RNA) · tumor vs normal (RNA) · all PRSS55 data types