PRSS54

Across TCGA cell cohorts, PRSS54 RNA expression is significantly associated with the mutation status of many other genes, with 169 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRSS54-associated genes across cancer lineages are UBN2, CILP2, and TTC16. Each is linked with PRSS54 in more than 2 cancer types. Because this analysis shows association rather than direction, both PRSS54-to-partner and partner-to-PRSS54 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UBN2 grouped by PRSS54-low versus PRSS54-high in LARGE_INTESTINE.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRSS54→partner) and Y-score (partner→PRSS54) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	UBN2 →	+3.345	+0.030	.001	<.001	3	3
SKIN	CILP2 →	+2.657	+0.059	.007	<.001	3	2
LUNG_SCLC	TTC16 →	+4.169	+0.026	.001	<.001	3	2
LUNG_SCLC	ADAM29 →	+3.584	+0.027	.003	<.001	3	2
BLOOD_Lymphoma	GLUD2 →	+4.867	+0.077	.009	<.001	3	2
BLOOD_Lymphoma	ALG3 →	+4.867	+0.043	.009	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 169 associations by consensus.

UBN2 by PRSS54 expression — LARGE_INTESTINE

Explore this box plot interactively →