PRSS54

Across TCGA pan-cancer cohorts, PRSS54 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of PRSS54’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where PRSS54 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PRSS54 is over-expressed in tumor.

KIRP and CHOL are the cancer types where PRSS54 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PRSS54 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Female	All	+0.095	.005	4	view →
CHOL	Male	All	+0.040	.036	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

PRSS54–KIRP

Open the KIRP breakdown →