PRSS54

Across TCGA pan-cancer cohorts, PRSS54 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated PRSS54 data layer compared with 4 for mutation status.

The strongest signal is observed in thyroid carcinoma (THCA), where higher PRSS54 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PRSS54 expression acts as an unfavorable survival marker, although some lineages such as PAAD and LIHC show a favorable association.

THCA, MESO, and KIRC are the cancer types where PRSS54 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	OS	Tertile	All	0.859	0.981	.001	69	view →
MESO	OS	Tertile	II,III,IV	0.425	0.609	.005	41	view →
KIRC	DFS	Tertile	All	0.707	0.834	.003	24	view →
PAAD	OS	Median	All	0.638	0.407	.001	23	view →
LIHC	DFS	Tertile	III,IV	0.461	0.192	.021	18	view →
COAD	OS	Tertile	All	0.823	0.886	.023	14	view →
KIRP	OS	Median	III,IV	0.638	0.272	.008	10	view →
ACC	DFS	Tertile	III,IV	0.398	0.707	.002	8	view →
HNSC	DFS	Tertile	All	0.543	0.699	.014	6	view →
DLBC	DFS	Quartile	III,IV	0.079	0.984	.045	6	view →
PRAD	DFS	Median	All	0.834	0.924	.001	6	view →
SARC	DFS	Quartile	All	0.771	0.558	.021	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

PRSS54–THCA (OS)

Open the THCA breakdown →