Across TCGA patient cohorts, PRSS38 mutation is significantly associated with the RNA expression of many other genes, with 4,556 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRSS38-associated genes across cancer lineages are GIT1, UMPS, and ZNF622. Each is linked with PRSS38 in more than 2 cancer types. Because this analysis shows association rather than direction, both PRSS38-to-partner and partner-to-PRSS38 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRSS38→partner) and Y-score (partner→PRSS38) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GIT1 →	+0.442	+2.010	<.001	.001	3	3
UCEC	UMPS →	+0.368	+3.515	.008	.002	3	3
UCEC	ZNF622 →	+0.371	+2.716	.006	.003	3	3
UCEC	GGNBP2 →	+0.378	+2.923	.002	<.001	3	2
UCEC	MRPL45 →	+0.561	+2.885	.001	<.001	3	2
CESC	LINC02500 →	+1.324	+6.144	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,556 associations by consensus.

Exploration

PRSS38 survival (RNA) · tumor vs normal (RNA) · all PRSS38 data types