Across TCGA pan-cancer cohorts, PRSS38 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated PRSS38 data layer compared with 3 for mutation status.
The strongest signal is observed in kidney chromophobe (KICH), where higher PRSS38 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PRSS38 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.
KICH, KIRC, and COAD are the cancer types where PRSS38 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.