Across TCGA pan-cancer cohorts, PRSS38 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of PRSS38’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where PRSS38 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PRSS38 is over-expressed in tumor, although a few such as PAAD show the opposite, repressed pattern.

THCA, PAAD, and LUSC are the cancer types where PRSS38 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PRSS38 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Female	All	+0.044	.001	6	view →
PAAD	Male	All	−0.075	.004	2	view →
LUSC	All	All	+0.031	.004	2	view →
LUAD	Male	All	+0.031	.021	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: PRSS38 RNA expression & survival · all PRSS38 data types