Across TCGA patient cohorts, PRSS38 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRSS38-associated genes across cancer lineages are p62 Lck ligand, Rad50, and ER-alpha. Each is linked with PRSS38 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRSS38-to-partner and partner-to-PRSS38 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRSS38→partner) and Y-score (partner→PRSS38) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.422	+3.584	<.001	.002	3	2
UCEC	Rad50 →	-0.186	-2.222	.036	.010	3	2
SKCM	ER-alpha →	+0.191	+2.182	.014	.033	3	1
SKCM	A-Raf_pS299 →	+0.229	+2.472	<.001	.010	3	1
SKCM	Fibronectin →	-0.582	-2.222	.002	.010	3	1
SKCM	Lck →	-0.322	-2.222	.022	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

Exploration

PRSS38 survival (RNA) · tumor vs normal (RNA) · all PRSS38 data types