Across TCGA cell cohorts, PRSS38 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRSS38-associated genes across cancer lineages are TCF23, PPIAL4F, and ZSCAN1. Each is linked with PRSS38 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRSS38-to-partner and partner-to-PRSS38 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRSS38→partner) and Y-score (partner→PRSS38) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TCF23 →	+0.005	+4.217	<.001	.001	3	2
LUNG_NSCLC_LUSC	PPIAL4F →	+0.076	+4.108	.004	.005	3	1
PANCREAS	ZSCAN1 →	+0.039	+5.000	<.001	.006	3	1
PANCREAS	TBL1Y →	+0.006	+5.614	<.001	.002	3	1
CNS	SCGB1C1 →	+0.253	+4.981	<.001	.008	3	1
BLOOD_Leukemia	GUCA2B →	+0.036	+5.969	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Exploration

PRSS38 survival (RNA) · tumor vs normal (RNA) · all PRSS38 data types