PRSS37

Across TCGA patient cohorts, PRSS37 mutation is significantly associated with the RNA expression of many other genes, with 2,725 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRSS37-associated genes across cancer lineages are CDCA2, RN7SL567P, and RPL23AP53. Each is linked with PRSS37 in more than 2 cancer types. Because this analysis shows association rather than direction, both PRSS37-to-partner and partner-to-PRSS37 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDCA2 grouped by PRSS37-low versus PRSS37-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRSS37→partner) and Y-score (partner→PRSS37) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CDCA2 →	+0.903	+3.335	<.001	.005	3	3
COAD	RN7SL567P →	+0.204	+3.375	<.001	.004	3	3
UCEC	RPL23AP53 →	+0.586	+3.711	<.001	<.001	3	3
UCEC	TIPIN →	+0.607	+3.721	<.001	<.001	3	3
UCEC	LATS2 →	+0.579	+3.459	.005	.005	3	2
UCEC	ACSL1 →	+0.945	+3.201	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,725 associations by consensus.

CDCA2 by PRSS37 expression — COAD

Explore this box plot interactively →