PRSS37

Across TCGA pan-cancer cohorts, PRSS37 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated PRSS37 data layer compared with 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PRSS37 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated PRSS37 expression acts as an unfavorable survival marker, although some lineages such as HNSC and MESO show a favorable association.

HNSC, MESO, and LGG are the cancer types where PRSS37 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	IV	0.425	0.253	.002	49	view →
MESO	OS	Median	All	0.377	0.193	.004	36	view →
LGG	OS	Median	All	0.868	0.748	<.001	26	view →
BRCA	OS	Median	II,III,IV	0.944	0.883	.002	25	view →
ESCA	DFS	Median	II,III,IV	0.450	0.264	.010	25	view →
THYM	DFS	Median	III,IV	1.000	0.399	.004	22	view →
KIRP	DFS	Tertile	IV	0.037	0.460	.004	22	view →
KIRC	DFS	Median	II,III,IV	0.441	0.603	.003	20	view →
LUAD	DFS	Median	II,III,IV	0.596	0.822	.001	18	view →
THCA	OS	Tertile	All	0.903	0.990	.014	10	view →
SARC	OS	Quartile	All	0.698	0.902	.007	9	view →
BLCA	OS	Median	II,III,IV	0.657	0.570	.031	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

PRSS37–HNSC (DFS)

Open the HNSC breakdown →