PRSS37

Across TCGA pan-cancer cohorts, PRSS37 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of PRSS37’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PRSS37 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PRSS37 is over-expressed in tumor, although a few such as KICH and UCEC show the opposite, repressed pattern.

KIRC, KICH, and UCEC are the cancer types where PRSS37 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PRSS37 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+0.070	<.001	8	view →
KICH	Male	All	−0.061	<.001	6	view →
UCEC	All	II,III,IV	−0.140	.014	4	view →
LIHC	All	All	+0.013	.005	3	view →
PAAD	Male	All	+0.250	.030	2	view →
ESCA	All	II,III,IV	+0.180	.029	2	view →
CHOL	All	All	+0.136	.013	1	view →
THCA	All	All	−0.057	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

PRSS37–KIRC

Open the KIRC breakdown →